Archive for the 'Health' Category
November 6th, 2013 by Wil
A while back I mentioned an event that occurred when I was trying to go to sleep one night. Why don’t I let me describe it?
…a couple nights ago I was lying half asleep and heard a clicking sound of the sort that houses often make — the wood of the frame settling a bit or something. My mind said, “Oh, an annoying sound… whatever,” but my body had a noticeable reaction. I felt that feeling of “tinglies” traveling from my neck down to my body. I presume these “tinglies” to be adrenaline released to the body from the brain and I presume the individual “pricks of tingliness” to be this adrenaline stimulating the synapses of various muscle nerves.
I doubt this is uncommon and I suspect most of us experience it. I, personally, experience it more in the morning. I’ll be lying there, pleasantly adrift, and a thought or sound will occur that jostles me from sleep. As much as I would like to go back to my reverie, I can feel my body waking up, against my wishes.
I’ve long suspected that the reason for this must be something to do with hormone production. Basically, we go to sleep and our body spends the night replenishing spent chemicals (like adrenaline and glucocorticoids, which, while I don’t fully understand, are similar to adrenaline in function.) In the morning we’ve got a vast reserve of these chemicals and it doesn’t take much to get them to be fired off.
Recently I was reading an article on coffee and it hinted at the same idea. We shouldn’t drink coffee in the morning, it said, because our body is already rich with excitatory cortisol. (Cortisol is a glucocorticoid which is a type of hormone.)
…if we are drinking caffeine at a time when your cortisol concentration in the blood is at its peak, you probably should not be drinking it. This is because cortisol production is strongly related to your level of alertness and it just so happens that cortisol peaks for your 24-hour rhythm between 8 a.m. and 9 a.m. on average (Debono et al., 2009). Therefore, you are drinking caffeine at a time when you are already approaching your maximal level of alertness naturally.
This jibes with my sense that some excitatory hormone is at its peak during the morning. So I was pretty much right about everything, as usual.
I’m not going to stop drinking coffee in the morning though.
September 14th, 2013 by Wil
A while back, I mentioned the girls of Le Roy, New York who, several years ago, began showing what appear to be—at least to the experts—symptoms of mass hysteria. The girls began experiencing Tourettes like body tics for which no environmental or biological cause could be found. This sort of thing is not that uncommon and has been reported throughout history.
The Atlantic has an interesting follow up on the story alleging that one women who experienced the symptoms effectively caught them off Facebook – she did not personally know any of the girls but “absorbed” their symptoms by reading about them. The article touches on two themes I often report on here. 1) The subconscious can cause bizarre, debilitating physical symptoms, and 2) We—society, humanity, etc.—are becoming overwhelmed with information. To wit…
Bartholomew said that mass hysteria spreads through sight and sound, and historically, one person would have to be in the same room as somebody exhibiting symptoms to be at risk of “catching” the illness. “Not anymore,” he says, noting that social media—“extensions of our eyes and ears”—speeds and extends the reach of mass hysteria. In a paper, he wrote, “Epidemic hysterias that in earlier periods were self-limited in geography now have free and wide access to the globe in seconds.” He says, “It’s a belief, that’s the power here, and the technology just amplifies the belief, and helps it spread more readily.”
Here’s a Dr. Drew episode featuring some of the girls.
August 24th, 2013 by Wil
Online mag The Verge has been doing some interesting stories lately including this one which notes that the future of psychiatry may be inside your stomach.
Her parents were running out of hope. Their teenage daughter, Mary, had been diagnosed with a severe case of obsessive–compulsive disorder (OCD), as well as ADHD. They had dragged her to clinics around the country in an effort to thwart the scary, intrusive thoughts and the repetitive behaviors that Mary felt compelled to perform. Even a litany of psychotropic medications didn’t make much difference. It seemed like nothing could stop the relentless nature of Mary’s disorder.
Their last hope for Mary was Boston-area psychiatrist James Greenblatt. Arriving at his office in Waltham, MA, her parents had only one request: help us help Mary.
Greenblatt also prescribed Mary a twice-daily dose of probiotics, the array of helpful bacteria that lives in our gut. The change in Mary was nothing short of miraculous: within six months, her symptoms had greatly diminished. One year after the probiotic prescription, there was no sign that Mary had ever been ill.
We all recognize there’s a relationship between our mood and gut. Anxiety often causes gastrointestinal issues and depression can result in a dull ache in the stomach. But we largely presume this relationship to be one way, our mind affecting our stomach.
For Greenblatt, this radical treatment protocol has actually been decades in the making. Even during his psychiatric residency at George Washington University, he was perplexed by the way mental disorders were treated. It was as if, he said, the brain was totally separate from the body. More than 20 years of work treating eating disorders emphasized Greenblatt’s hunch: that the connection between body and mind was more important than conventional psychiatry assumed. “Each year, I get more and more impressed at how important the GI tract is for healthy mood and the controlling of behavior,” Greenblatt said. Among eating disorder patients, Greenblatt found that more than half of psychiatric complaints were associated with problems in the gut — and in some patients, he says he has remedied both using solely high-dose probiotics, along with normalizing eating.
I’m reminded of a segment in one of Malcolm Gladwell’s books where he described the work of some scientists tracking facial expression. These two fellows were spending all their time making faces of various emotional character at each other. After two weeks of making sad or depressed faces one of the guys reported that he was actually feeling miserable. The relation between mood and face was a two way street. Maybe the same is true with the stomach.
June 26th, 2013 by Wil
First, a little update: I’m now back in the U.S. and back to blogging.
On my brief vacay there, I continued to contemplate the advent of 3D printers and their possible affects on the future. Today I started thinking about whether 3D printers could produce drugs (via a method similar to how such printers could potentially print food.) Specifically, I was wondering whether drug hackers could reverse engineer existing, often costly, prescription drugs and upload recipes for these drugs onto the web. These recipes could be downloaded and certain printers could “print” the drugs. (People doing the printing would still need the raw materials for the drugs of course; the printer would just assemble the materials. But these pirated drugs would clearly be much cheaper than the legal, patented versions.)
As is usually the case with these ruminations, I found that many people had already been thinking about the topic. I offer the podium to the libertarian Mises.org.
Now imagine a not-too-distant future world where 3D printers of all types are becoming more prevalent. It is easy to imagine machines designed to fabricate pharmaceuticals. If a new life-saving drug hits the market and costs thousands of dollars per year (due to the combination of the patent monopoly, the FDA system, medical licensure of doctors, government regulation of prescription drugs, and other state interventions), some consumers may prefer to “make their own” generic version, using reverse-engineered “recipes” floating around the web programmed into their own, or a friend’s, 3D drug printer. Just as the hacker community quickly cracks new iOS releases on the iPhone, say, it is not hard to imagine the drug-hacker community reverse engineering the composition and manufacturing method of pharmaceuticals–especially in this near future world with increasingly sophisticated and cheap analyzing and related equipment.
Now, these home-made generic pharmaceuticals might not be as good as the official ones. They might even be more dangerous. But to save thousands of dollars a year, many people might turn to this.
From there the post examines legal and enforcement issues related to drug hacking. Interesting stuff.
May 1st, 2013 by Wil
Harvard Magazine has an interesting look at the study of placebos – fake medical cures that should have no effect but often do.
Two weeks into Ted Kaptchuk’s first randomized clinical drug trial, nearly a third of his 270 subjects complained of awful side effects. All the patients had joined the study hoping to alleviate severe arm pain: carpal tunnel, tendinitis, chronic pain in the elbow, shoulder, wrist. In one part of the study, half the subjects received pain-reducing pills; the others were offered acupuncture treatments. And in both cases, people began to call in, saying they couldn’t get out of bed. The pills were making them sluggish, the needles caused swelling and redness; some patients’ pain ballooned to nightmarish levels. “The side effects were simply amazing,” Kaptchuk explains; curiously, they were exactly what patients had been warned their treatment might produce. But even more astounding, most of the other patients reported real relief, and those who received acupuncture felt even better than those on the anti-pain pill. These were exceptional findings: no one had ever proven that acupuncture worked better than painkillers. But Kaptchuk’s study didn’t prove it, either. The pills his team had given patients were actually made of cornstarch; the “acupuncture” needles were retractable shams that never pierced the skin. The study wasn’t aimed at comparing two treatments. It was designed to compare two fakes.
Perhaps most interesting: placebos work even when patients know they are placebos.
But years of considering the question led him to his next clinical experiment: What if he simply told people they were taking placebos? The question ultimately inspired a pilot study, published by the peer-reviewed science and medicine journal PLOS ONE in 2010, that yielded his most famous findings to date. His team again compared two groups of IBS sufferers. One group received no treatment. The other patients were told they’d be taking fake, inert drugs (delivered in bottles labeled “placebo pills”) and told also that placebos often have healing effects.
The study’s results shocked the investigators themselves: even patients who knew they were taking placebos described real improvement, reporting twice as much symptom relief as the no-treatment group. That’s a difference so significant, says Kaptchuk, it’s comparable to the improvement seen in trials for the best real IBS drugs.
The article lists various caveats and skepticism but overall it seems like there’s something to the placebo treatment.
April 30th, 2013 by Wil
I’ve long been a part of a email list which discusses the topic of repetitive strain injuries (RSI). Whereas RSI is not much of a problem for me these days, I still follow the discussions on the list. There’s really two camps of people on the list: 1) People who believe de-stressing techniques such as meditation/yoga will alleviate RSI, and 2) People who believe RSIs are largely physical, structural problems that can be relieved via practices like massage/surgery/ergonomics/electrotherapy.
If you’ve been reading this blog for any length of time you know I reside in the former group. (Truthfully, most people on the list are probably open to both ideas but they clearly have a dominant belief.)
Meditation comes up a lot on the list. Today someone was addressing an obvious question: If meditation is so great for you, why is it so hard (and often boring?) Why does our mind resist calm? His reason was sound and thought provoking.
Lots of meditation has shown me how my mind is built to resist the ‘inner journey’ of using yoga and deep relaxation to slow it down and get it to release stuff and let me see how it works. My theory is it has to be like this because if we all went after the bliss this can bring we would all have been a bunch of wimpy meditators and eaten by predators a long time ago!
It makes sense – in the world of our ancestors we had to pay attention! We couldn’t be sitting around in nirvana. Our mind resists efforts geared towards its deconstruction.
He continues on a tangent that sounds a little elitist but is probably correct.
Evolution favours diversity – only some can do this inner journey which produces the sages [who] keep us from going too crazy and destroying ourselves. Others cant and are useful for more real world things.
There’s another possible theory here. Earth is under observation by an aggressive alien lizard race who plan on conquering us. They planted the concept of meditation in our minds hoping that the practice will spread until most of humanity exists in a meditative trance. Then they will attack our planet, eat our young and rape our grandmothers!
But I’m just being silly. It’s nothing to worry about. Go back to meditating.
April 18th, 2013 by Wil
CBS has a report noting that famous people in performance fields (sports, music etc) die younger than famous people in more boring fields (business, military.) I would have guessed performance stress would be the major killer, perhaps indicated by heart attacks, but cancer seems to the be the major culprit, indicating that people in these demographics make poor health decisions (smoking, booze, etc.) Some intellectuals have theories about the psychological mechanisms at work.
Study author Richard Epstein, director of the Clinical Informatics & Research Centre at The Kinghorn Cancer Centre in St. Vincent’s Hospital in Sydney, said in a press release that while the study can’t prove that choosing the performing arts or an athletic career means choosing an earlier death, it does bring up some interesting points.
“First, if it is true that successful performers and sports players tend to enjoy shorter lives, does this imply that fame at younger ages predisposes to poor health behaviors in later life after success has faded? Or that psychological and family pressures favoring unusually high public achievement lead to self-destructive tendencies throughout life? Or that risk-taking personality traits maximize one’s chances of success, with the use of cigarettes, alcohol or illicit drugs improving one’s performance output in the short term? Any of these hypotheses could be viewed as a health warning to young people aspiring to become stars,” he commented.
Honey Langcaster-James, a psychologist who specializes in celebrity behavior, warned the BBC that there are very few celebrities so the pool isn’t big enough to really study the effects of fame on people’s lifespan. Still, she had some theories on why performance-related fame may lead to an earlier demise, including “the pressure to live up to a public image, which can lead to risky behaviors” or “particular personal characteristics predispose people to wanting a career in the public arena.”
However, there’s not a wide spread in death ages; a sports performer is, at worst, losing 5 years by choosing their vocation. And famous people still seem to live longer than the national average.
April 10th, 2013 by Wil
Scientist have created transparent brains, the NY Times reports. (There’s some cool animations at the link.)
Scientists at Stanford University reported on Wednesday that they have made a whole mouse brain, and part of a human brain, transparent, so that networks of neurons that receive and send information can be highlighted in stunning color and viewed in all their three-dimensional complexity without slicing up the organ.
One might ask, “why should I give a shit?” Personally, I suspect this new era of deep brain visualization and research is going to reveal that personality and activity of the mind is closely tied to brain structure. As a result, people choices are essentially limited to their brain components. As an example, un-empathic people may not be simply assholes, but people missing some degree of the empathy “toolset*” in their brain. This opens up a whole well of debate about free will, choice etc. – a debate that may end up affecting our legal system.
* I’m using this term to represent the neural area or network that might be integral to a certain function like empathy.
I do think various drugs an therapies can affect people’s mental “toolsets” (postively or negatively) but I doubt we can radically alter a person’s mental function. Unless we get into some sci-fi transplanting of brain tissue. Perhaps the rich empathy section of some namby-pamby liberal’s brain could be transplanted into that of a hardened psychopath making him a lover of puppies.
April 8th, 2013 by Wil
The website io9 notes that scientists have figured out how to alter genes to extend life spans! Of, um, yeast, but what they learn could be applicable to humans.
Longo’s group put baker’s yeast on a calorie-restricted diet and knocked out two genes – RAS2 and SCH9 – that promote aging in yeast and cancer in humans.
“We got a 10-fold life span extension that is, I think, the longest one that has ever been achieved in any organism,” Longo says. Normal yeast organisms live about a week.
“I would say 10-fold is pretty significant,” says Anna McCormick, chief of the genetics and cell biology branch at the National Institute on Aging (NIA) and Longo’s program officer. The NIA funds such research in the hope of extending healthy life span in humans through the development of drugs that mimic the life-prolonging techniques used by Longo and others, McCormick adds.
Most interesting on the page are the comments which quickly point out the downsides of humans living a long time.
How would it affect the economy? Would money decrease in value if they had to make enough for so many people in effort to keep as little poverty as possible? How long would food last? Would we use it on cattle and pigs and chickens and other farm animals? What about fruits and vegetables? Where would everyone live? Would the entire planet turn into one huge city? Where would we grow our food? Would we just build up and up and up for housing developments? How many houses and cars would be made? With that many houses and cars being used, what would happen to our atmosphere?
It’s clear that if human lifespan extension is possible, only a select few should be granted this gift. Only people of exceptional intellect, taste, ability and good looks.
You know who I’m thinking of.
April 1st, 2013 by Wil
I’m always pointing out evidence showing that things presumed to be bad for you – booze, coffee, massive internet porn consumption etc. – are actually good for you. Here’s the latest (from the NY TImes.)
People who live on the Greek island of Ikaria are known to have remarkably high life expectancies, and researchers have been studying them carefully to learn why. Now a new report suggests that one reason may be the coffee they drink.
He and his colleagues found that older islanders who drank the boiled coffee had better functioning endotheliums — the layer of cells that line blood vessels.
Of course, it’s not just the coffee. The people of Ikaria live rather chill lives.
“It has to do with their way of living,” Dr. Siasos said. “People sleep over eight hours a night, there is increased socializing, and they have much less stress than people in Athens.”
Further evidence that modern society is doing everything wrong and aliens should enslave our planet.